Visit
Fri 05/30

Towards Precision Oncology: A Predictive, Causal, and LLM Lens

The Institute of Artificial Intelligence for Digital Health invites you to attend its monthly seminar series, which will feature Dr. David Sontag, a Professor at MIT in the Department of Electrical Engineering and Computer Science (EECS), the Institute for Medical Engineering and Science (IMES), and the Computer Science and Artificial Intelligence Laboratory (CSAIL).

This talk explores the development of machine learning tools for personalized cancer treatment, using multiple myeloma and breast cancer as case studies. Dr. Sontag presents a clinical decision support system that forecasts patient-specific outcomes under different therapies by modeling biomarker trajectories and survival jointly. Leveraging a transformer-based architecture, the system supports more informed, individualized decisions. Next, to expand the amount of data available to learn such models, he describes how large language models can be used to scalably abstract clinical data from unstructured medical records. Finally, Dr. Sontag shares results from a physician survey study examining how clinicians interpret and act on ML predictions and introduce a framework to assess the causal validity of model outputs using falsification techniques. The talk highlights a path forward for AI in oncology that is both data-driven and clinically grounded.

Speaker Bio

Dr. David Sontag is a Professor at MIT in the Department of Electrical Engineering and Computer Science (EECS), the Institute for Medical Engineering and Science (IMES), and the Computer Science and Artificial Intelligence Laboratory (CSAIL). He is also a co-founder and CEO at Layer Health. Dr. Sontag’s research interests are in machine learning and artificial intelligence. As part of IMES, he leads a research group that aims to transform healthcare using machine learning. Dr. Sontag joined MIT in 2017 from New York University, where he was Assistant Professor in Computer Science and Data Science, and before this a postdoctoral researcher at Microsoft Research New England. Dr. Sontag received the Sprowls award for outstanding doctoral thesis in Computer Science at MIT in 2010, best paper awards at the conferences EMNLP, UAI and NeurIPS, and a NSF CAREER Award. Dr. Sontag received a B.A. from the University of California, Berkeley.